In developing Clipnosis, researchers found that, as with scruffing, not all cats were susceptible to the effects of Clipnosis, and the effectiveness can vary among cats.
According to research done on the subject, about 70% of cats are affected by scruffing and / or Clipnosis. Tarttelin (1991) reported that 67% of cats responded to clipping, and Gagnon (2006) found that 69% of cats responded scruffing (using two fingers instead of clips). Our own research included a survey sent to veterinarian and vet techs who used Clipnosis, and we found that 66% of cats exhibited calmer behavior after application of the clips, and 79% of vets and techs rated Clipnosis as being “very effective” or “somewhat effective.”
During clinical research, it was found that scruffing provided a reasonable prediction of whether or not cats would respond positively to Clipnosis. If a cat responds to scruffing, the odds are very good that it will also respond to Clipnosis.
In addition, the effectiveness of Clipnosis can vary from cat to cat. We have seen examples of cats falling over and appearing catatonic after application of Clipnosis, but this reaction is not typical. Most cats do exhibit calmer behavior
after application, however. Cats also tend to become more tolerant and accepting of the clips after repeated experience with them. It’s also very important to reiterate that calm, quiet cats respond much better to Clipnosis than do agitated cats. In the clinic, application of Clipnosis should be done before attempting any procedures, and not as a last resort. Arouse cats are less likely to respond positively to Clipnosis.
The bottom line is, Clipnosis is effective with most cats, so results may vary depending on the cat and the environment in which Clipnosis is applied.
Source: Pinch-induced behavioral inhibition (‘clipnosis’) in domestic cats, Megan E Pozza BS, Judi L Stella BS, Anne-Claire Chappuis-Gagnon DVM, Susan O Wagner DVM, MS, DACVIM, CA Tony Buffington DVM, PhD, DACVN
Journal of Feline Medicine & Surgery
Volume 10, Issue 1, February 2008, Pages 82-87